Synthesis and modification of crystalline SBA-15 nanowhiskers as a pH-sensitive metronidazole nanocarrier system

Publication date: Available online 15 November 2018Source: International Journal of PharmaceuticsAuthor(s): Arash Yunessnia lehi, Hamidreza Shagholani, Ali Nikpay, Mohsen Ghorbani, Mohammad Soleimani lashkenari, Maryam SoltaniAbstractClinical resistance to drugs and diminution in their side effects have become great issues for pharmacologists. In veterinary medicine, parasites like Trichomonas gallinae are of veterinary, hygienic and economic importance and can be treated by metronidazole. Unfortunately, scientific evidence has been reported about its resistance and serious side effects in trichomoniasis. In this research, it was attempted to introduce a new procedure to lower side effects of the drug molecules and also, enhance the treatment of disease. Whisker-formed SBA-15 nanoparticles were utilized for the first time in this issue. They had mesoporous structures which metronidazole molecules could be trapped in them. Additionally, these crystalline nanowhiskers were modified with tannic acid to make the release process better. The branches of tannic acid covered the opening of pores in crystalline SBA-15 nanowhiskers and restricted the drug from fast release. It caused a controlled metronidazole release in the smart drug delivery. These nanocarriers were completely tested by several experiments. Whisker-like SBA-15 nanocrystals had a mesopore volume of 0.5931 cm3/g, pore diameter of 6.06 nm and surface area of 491.38 m2/g. Based on TGA analysis, 10% of tannic acid was co...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research