Prolonged hyponatremia due to hypopituitarism in a patient with non-ST-elevation myocardial infarction

Publication date: Available online 30 August 2014 Source:Journal of Cardiology Cases Author(s): Kyohei Marume , Yuichiro Arima , Motoyuki Igata , Takeshi Nishikawa , Eiichiro Yamamoto , Megumi Yamamuro , Kenichi Tsujita , Tomoko Tanaka , Koichi Kaikita , Seiji Hokimoto , Hisao Ogawa A 58-year-old man was admitted for non-ST-elevation myocardial infarction. A medicated stent was used for severe coronary artery stenosis. However, consciousness level progressively deteriorated after angioplasty. Computed tomography showed no brain lesion but laboratory tests showed hyponatremia (serum sodium: 113meq./l) and urine analysis showed syndrome of inappropriate antidiuretic hormone secretion (SIADH). SIADH was first suspected to be drug-induced by enalapril. However, hyponatremia persisted even after withdrawal of enalapril and required oral sodium intake. Hormone assays indicated secondary adrenal insufficiency, which was caused by adrenocorticotropic hormone (ACTH) deficiency. Furthermore, in addition to ACTH deficiency, adult growth hormone deficiency was diagnosed following tests. Treatment with hydrocortisone relieved hyponatremia and re-institution of enalapril did not reduce serum sodium concentration. The final diagnosis was hyponatremia caused by hypopituitarism. <Learning objective: Secondary adrenal insufficiency with subsequent hypopituitarism should be suspected in cases with sudden-onset and prolonged hyponatremia in acute illness. Furthermore, the m...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research