A giant splenic hamartoma associated with hematologic disorders: A case report

ConclusionIn patients with splenic tumors, splenectomy is indicated in cases where malignancy cannot be excluded, when symptoms occur, or in the rare cases of consequent hematologic disorders.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research

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ConclusionsMutations of MEFV can contribute to increase inflammatory expression in other diseases, as Kawasaki disease.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
ConclusionsSevere hypercalcemia and aplastic anemia are potential paraneoplastic syndromes of adult T-type lymphoblastic lymphoma, with fatal short-term outcome.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
We report data from phase Ib dose-finding and phase II expansion cohorts of LEN + etoposide + ifosfamide in pts with r/r osteosarcoma.MethodsPts were aged 2 to  ≤ 25 years with r/r osteosarcoma and
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsCurrently available systemic therapies are not specific for advanced ES, have a limited response durability and low tolerability. This is the largest US-based rw study that provides benchmarking treatment efficacy and safety data for development of standard of care therapies for ES. Table:1687P Real-world outcomes by line of therapy1L N  = 742L+ N = 46rwORR (95% CI), %14.9 (7.7-25.0)9.4 (4.4-17.1)Median rwDOR (95% CI), wks14.5 (9.1-22.6)19.6 (3.1-24.3)rwDCR (95% CI), %20.3 (11.8-31.2)19.8 (12.4-29.2)Median rwPFS (95% CI), wks11.0 (7.3-29.9)26.0 (13.9-32.0)Median OS (95% CI), wks66.3 (...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The presentation of bone marrow failure and multiorogan injury associated with ARS in the New Zealand White rabbit model is consistent with that described in the canine, swine, non-human primate, and in humans. The hemorrhagic syndrome associated with the ARS in rabbits is characterized by thrombocytopenia and hemostasis dysfunction, which appear to underlie the development of multiorgan dysfunction following TBI to rabbits. Taken together, the rabbit recapitulates the pathogenesis of ARS in humans, and may present an alternative small animal model for medical countermeasure pilot efficacy screening, dose-find...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Conclusions: Severe malaria is a highly frequent event in pregnant women, without differences by Plasmodium species. It shows early recognizable dangers signs. Hospital under-reporting was identified in 88% of severe cases as well as a lack of laboratory tests for a more comprehensive diagnosis. A protocol for the clinical diagnosis of pregnant women with malaria is required. PMID: 31529822 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Conclusion: This case demonstrates the importance of a broad differential diagnosis for a child presenting with leg pain and fever. PMID: 31528139 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
ConclusionSerotonin syndrome should be considered in patients on multiple serotonergic agents on the background of end ‐stage renal disease. Prompt recognition and distinction from lupus activity can significantly impact management decisions.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: APLAR GRAND ROUND CASE Source Type: research
ConclusionsThe final conceptual model, which includes salient symptoms and impacts of congenital thrombotic thrombocytopenic purpura and reflects the disease burden, was derived by integrating inputs from the literature review, expert opinion, and patient interviews, and will be used to develop a congenital thrombotic thrombocytopenic purpura –specific, patient-reported outcome instrument.
Source: The Patient - Patient-Centered Outcomes Research - Category: International Medicine & Public Health Source Type: research
ConclusionThrombotic thrombocytopenic purpura is a rare condition that can be acquired. Our case is rare because it represents the first report of diclofenac potassium-induced thrombotic thrombocytopenic purpura with subjacent complement activation and dysregulation. Early recognition and aggressive management led to a favorable outcome.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
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