Chronic myeloid leukemia with complex karyotypes: Prognosis and therapeutic approaches
ConclusionCML classification using different features such as Ph and ACAs can play a decisive role in the evaluation of treatment responses in patients, for example, CML patients with Ph negative and monosomy 7 develop MDS or CML patient –Y and extra copy of Ph have a good response to tyrosine kinase inhibitors, therefore, classifications according to Ph and ACAs play an important role in choosing better treatment protocols and therapeutic strategies. Karyotype analysis in CML patients with complex karyotype shows unrandom pattern so ACAs can be great clue in medical guidelines.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Ali Amin Asnafi,
Zeinab Deris Zayeri,
Saeid Shahrabi,
Kazem Zibara,
Tina Vosughi Tags: REVIEW ARTICLE Source Type: research
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