Analyses of genomic changes in chromosome 17 and P53 gene in oral squamous cell carcinoma patients

This study was performed retrospectively on 30 cases diagnosed with OSCC through FISH technique. Molecular cytogenetic techniques, using fluorescence in situ hybridization with chromosome-specific DNA probes, facilitate the confirmation of presumed chromosomal aberrations with high sensitivity and specificity.ResultsOut of 30 cases 29 represent molecular alteration. About 70 % of cases presented chromosome 17 polysomy and only 20% of cases had chromosome 17 monosomy. 58% of samples revealed p53 gene amplification and 37% of them p53 deletion.DiscussionHigh frequency of correlation between molecular changes in chromosome 17 and p53 gene with OSCC indicates towards their critical role in development of this disease.AbstractOral squamous cell carcinoma (OSCC) is widely recognized as the most common type of head and neck cancer and is an important cause of death and morbidity. Oral cancer is one of the major health problems in India and Indian subcontinent countries. Tobacco is the main etiological factor for oral carcinoma. Human papilloma virus, ethnicity, socio-economic status, dietary deficiencies and poor oral hygiene are other etiological factors of oral carcinoma. In Indian population, nearly 10% of the cancers that develop annually belongs to this category. Deactivation and unregulated expression of oncogenes and tumor suppressor genes may be involved in the pathogenesis of oral squamous cell carcinoma. The genomic change results in numerical aberrations in chromosomes 17...
Source: Journal of the Anatomical Society of India - Category: Anatomy Source Type: research