Multifunctional magnetic cargo-complexes with radical scavenging properties.

Multifunctional magnetic cargo-complexes with radical scavenging properties. Mater Sci Eng C Mater Biol Appl. 2019 Jan 01;94:608-618 Authors: Lungoci AL, Turin-Moleavin IA, Corciova A, Mircea C, Arvinte A, Fifere A, Marangoci NL, Pinteala M Abstract Core-shell magnetic nanoparticle synthesis offers the opportunity to engineering their physical properties for specific applications when the intrinsic magnetic properties can be associated with other interesting ones. The purpose of this study was to design, synthesize, and characterize core-shell magnetic nanoparticles that mimic superoxide dismutase activity offering the possibility of guidance and therapeutic action. We proposed, for the first time, the synthesis and characterization of the nanocarriers comprised of magnetite nanoparticles functionalized with branched polyethyleneimine of low molecular weight (1.8 kDa) permitting the loading of the protocatechuic acid or its inclusion complex with anionic sulfobutylether-β-cyclodextrin for active drug delivery, in order to combine the useful properties of the magnetite and the protocatechuic acid antioxidant effect. NMR and DSC analyses confirmed the formation of the inclusion complex between sulfobutylether-β-cyclodextrin and protocatechuic acid, while structural and compositional analyses (FT-IR, TEM, XRD) revealed the synthesis of the multifunctional magnetic systems. Due to the possibility of being formulated as blood system i...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research