The gut microbiota of hand, foot and mouth disease patients demonstrates down ‐regulated butyrate‐producing bacteria and up‐regulated inflammation‐inducing bacteria

This study explored the gut microbiota of children with hand, foot and mouth disease (HFMD).MethodsWe enrolled 15 cases with HFMD admitted to the West China Second Hospital, Sichuan University, China, from July to September 2016 at a median age of three years. The controls were 15 healthy children of a similar age who underwent routine health examinations at the hospital during the same period. Gut microbiota was analysed using high throughput 16S ribosomal deoxyribonucleic acid  sequencing.ResultsThe gut microbiota in the HFMD patients was distinct from the controls. Compared with the controls, the composition of gut microbiota in the HFMD cases represented a reduction of two butyrate ‐producing bacteria,Ruminococcus (0.73 ±1.28 versus 7.78 ±20.01, p=0.026) andRoseburia (0.67 ±1.69 versus 1.61 ±3.27,p=0.024) and an up‐regulation ofEscherichia (5.26 ±10.50 versus 1.59 ±5.90,p
Source: Acta Paediatrica - Category: Pediatrics Authors: Tags: Regular Article Source Type: research

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This study provides a high cost-effective method of designing a multivalent enterovirus vaccine protect against a wide range of enterovirus pathogens. PMID: 32247566 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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