High Concordance of BRAF Mutational Status in Matched Primary and Metastatic Melanoma

ConclusionsOur results suggest that discordance of BRAF mutational status between primaries and metastases is a rare occurrence. In one case, immunohistochemistry provided strong evidence that initial PCR testing had provided a false negative result due to low tumour volume. Thus, in cases where tissue is is difficult to obtain from a metastasis or unavailble, the primary tumour can be used with confidence.This article is protected by copyright. All rights reserved.

Source: Journal of Cutaneous Pathology - November 14, 2018 Category: Pathology Authors: David Cormican, Ciaran Kennedy, Sandra Murphy, Reiltin Werner, Derek G. Power, Cynthia CBB Heffron Tags: ORIGINAL ARTICLE Source Type: research