Validation of Serum Test for Advanced Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis

We analyzed markers of fibrosis in serum samples from patients with nonalcoholic fatty liver disease (NAFLD), assessed by liver biopsy. We used serum levels of markers to develop an algorithm to discriminate patients with advanced fibrosis from those with mild or moderate fibrosis and validated its performance in 2 independent cohorts of patients with NAFLD.

Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Rohit Loomba, Anjali Jain, Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Seema Singh, Claire Faulkner, Lisa Richards, Kelly D. Hester, Lauren Okada, Xiao-jun Li, Larry Mimms, Manal F. Abdelmalek Source Type: research