Exploring the relationship between Endothelin-1 and peripheral inflammation in multiple sclerosis

Identifying pathways linking neuroinflammation and neurodegeneration is essential to help prevent disability progression in people with multiple sclerosis (MS). Endothelin-1 (ET-1) is a potent vasoconstrictor thought to contribute to cerebral hypoperfusion and tissue damage in MS. Its link with the neuroinflammatory process remains poorly investigated.

Source: Journal of Neuroimmunology - November 15, 2018 Category: Allergy & Immunology Authors: Natalia P. Rocha, Gabriela D. Colpo, Javiera Bravo-Alegria, John A. Lincoln, Jerry S. Wolinsky, John W. Lindsey, Antonio L. Teixeira, Leorah Freeman Source Type: research