“Pikachu‐shaped” flap for extramammary Paget's disease
International Wound Journal, EarlyView.
To determine the prevalence, impact and management of acute and chronic pain amongst youth aged 5-18 years with cerebral palsy, attending outpatient rehabilitation services.
Extramammary Paget's disease (EMPD) is a rare disease with an estimated prevalence of 0.1 to 2.4 per 1,000,000 person-years. Metastatic EMPD has a poor prognosis with a 5-year survival of approximately 7%. Local therapy is the only curative option with surgery being recommended for resectable disease. It is therefore crucial to be able to stage such patients appropriately. The utility of 18F-FDG PET/CT for this disease is not well established. We share a case on how 18F-FDG PET/CT was used to stage metastatic EMPD.
The molecular weight of methotrexate (MTX) makes cutaneous penetration difficult. Oxygen flow could enhance the skin permeation of MTX diluted in the LP3 carrier system. This pilot study aims to assess the efficacy, safety and tolerance of oxygen-flow-administered (OFA)-LP3-MTX3% for treating superficial skin cancers. Patients with superficial basal cell carcinoma (sBCC)(n=12), extramammary Paget ’s disease (EMPD)(n=5), mycosis fungoides classic type (CMF) (n=10) and folliculotropic (FMF) (n=6) were included in the study and were treated with 4 weekly applications of OFA-LP3-MTX3%.
Authors: Cosgarea I, Zaremba A, Hillen U Abstract Extramammary Paget's disease (EPD) is a rare, slowly growing, cutaneous adenocarcinoma with an incidence of 0.1-2.4 per 1,000,000 inhabitants. Histologically, EPD is characterized by the presence of epidermal Paget's cells, similarly to mammary Paget's disease. The EPD is typically divided into primary EPD (type I) and secondary EPD (type II associated with colorectal carcinoma and type III associated with urogenital carcinoma). From a clinical point of view, EPD is unspecific commonly mimicking chronic inflammatory skin disorders. This unsp...
Extramammary Paget Disease (EMPD) is a rare intraepithelial adenocarcinoma that arises in apocrine gland bearing skin and presents as a chronic rash that resembles several disorders such as eczema, cutaneous T cell lymphoma, Langerhans cells histiocytosis, intraepithelial neoplasia, fungal infections and psoriasis. EMPD is often associated with underlying or distant malignancies. The epidemiology of EMPD in Canada is poorly understood. Further, the risk of developing second malignancies in Canadian EMPD patients was not evaluated prior to the presented study.
PMID: 31475341 [PubMed - in process]
Malassezia yeast plays a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget ’s disease (EMPD) is an adenocarcinoma of apocrine origin and, except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate 1) the immunomodulatory effects of Mala ssezia metabolites on normal human keratinocytes (NHKCs), focusing on inter...
Paget disease involves an excessive amount of bone resorption and haphazard bone growth. Refresh your knowledge with this illustrated overview of the condition.Osmosis
CONCLUSIONS: This study reveals the expression of PDL-1 and ER and confirms the expression of HER2/AR in VPD; new bases are provided to design multicenter clinical trials on personalized target therapies. PMID: 31297606 [PubMed - indexed for MEDLINE]
An error was made in the July 2019 issue of Dermatologic Clinics (Volume 37, Issue 3) in article titled Extramammary Paget Disease, by Drs. Bradley Merritt, Catherine Degesys, and David Brodland regarding Figures 1 and 2.