Ultrasonography and detection of subclinical joints and tendons involvements in Systemic Lupus erythematosus (SLE) patients: A cross-sectional multicenter study

ConclusionUS may be useful to assess joint involvement in SLE patients but did not significantly change SLEDAI score.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Authors: Villamil-Gómez WE, Calderón-Gomezcaseres Á, Rodriguez-Morales AJ Abstract Not available. PMID: 30882389 [PubMed - in process]
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Abstract A preterm, low birth weight (1.45 kg) baby boy, delivered at 32 weeks, was admitted to the neonatal ICU with a low APGAR score assessment of Activity/muscle tone, Pulse/heart rate, Grimace, Appearance, and Respiration. Each criterion is graded from 0 to 2, and a final score is obtained by their sum (0-10). Our patient had a score of 3; poor feeding; failure to thrive; and a red, scaly skin eruption on the face and extremities. Physical examination showed erythematous, crusted lesions over the forehead, cheeks, neck, and arms. His mother had a history of two spontaneous abortions in the previous 2 years an...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
Abstract A 47-year-old white woman presented to our clinic complaining of recalcitrant warts on her trunk and extremities. She had an extensive past medical history including immunodeficiency of unknown origin, pulmonary hypertension, rheumatoid arthritis, and systemic lupus erythematosus, for which she was being treated with chronic immunosuppressive therapy with methylprednisolone and belimumab. The patient had previously failed treatments at an outside facility with liquid nitrogen, trichloroacetic acid, topical cidofovir, imiquimod, topical 5-fluorouracil, intralesional candida antigen, pulsed-dye laser (Vbeam...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
Abstract Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder that is characterized by prevalent hypertension, renal injury, and cardiovascular disease. Numerous studies report a low prevalence and/or impaired function of regulatory T cells (TREG) in both patients with SLE and murine models of the disease. Evidence suggests that TREG dysfunction in SLE results from a deficiency in interleukin (IL)-2. Recent studies report that low dose IL-2 therapy expands TREG in mouse models of SLE, but whether expanding TREG protects against hypertension and renal injury during SLE is unclear. To exam...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Arthritis&Rheumatology, EarlyView.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Letters Source Type: research
ObjectiveTo clarify the significance of immunometabolism in systemic lupus erythematosus (SLE), and to determine the effect of calcium/calmodulin ‐dependent protein kinase 4 (CaMK4) on T cell metabolism.MethodsMetabolomic profiling was performed using capillary electrophoresis mass spectrometry in naive T cells from MRL/lpr mice treated with anti ‐CD3/CD28 antibodies in the absence or presence of a CaMK4 inhibitor (KN‐93). The expression of GLUT1 and CaMK4 in CD4+ T cells from healthy controls (n = 16), patients with inactive SLE (n = 13), and patients with active SLE (n = 14) was examined by flow cytometry and quant...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
This study was aimed to seek higher remission rate of lupus nephritis using a combined strategy.MethodA 24-week trial was conducted in 17 rheumatology or nephrology centers in China. A total of 191 lupus nephritis patients were randomized to follow a combined immunosuppressive treatment (CIST) with intravenous cyclophosphamide, an oral immunosuppressive agent, namely mycophenolate mofetil, azathioprine or leflunomide, and hydroxychloroquine (n = 95), or receive intravenous cyclophosphamide alone (n = 96) for 24 weeks. Glucocorticoid was given to both groups. The primary end point was a comp...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 18 March 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): De Carolis Sara, Moresi Sascia, Rizzo Francesca, Monteleone Giuseppina, Tabacco Sara, Salvi Silvia, Garufi Cristina, Lanzone AntonioAbstractAutoimmune diseases (AIDs) are associated with strong female preponderance and often present before or during the reproductive years, consequently pregnancy and breastfeeding are topics of major interest for these patients. AIDs show different response to pregnancy: some ameliorate, other remain unchanged and several AIDs aggravate. The response of the AIDs...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
CHICAGO—The 2018 ACR/ARHP Annual Meeting session on genetic mimics of rheumatic disease began with a description of a patient who presented with the symptoms of childhood-onset lupus but instead had a well-defined genetic disease: lysinuric protein intolerance (LPI). Lindsay Burrage, MD, PhD, assistant professor of molecular and human genetics at Baylor College of Medicine, Houston,... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Meeting Reports 2018 ACR/ARHP Annual Meeting Fabry disease genetic disease lysinuric protein intolerance mimics Source Type: research
CHICAGO—At the 2018 ACR/ARHP Annual Meeting, rheumatologist project volunteers for the ACR’s Collaborative Initiatives talked about their efforts to educate primary-care providers, patients and families in their communities about systemic lupus erythematosus (SLE). Their goal is to facilitate timely diagnosis and treatment of lupus, especially in underserved communities. Health Disparities Health disparities, or differences in health... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Meeting Reports SLE (Lupus) 2018 ACR/ARHP Annual Meeting Community Health Worker Lupus Clinical Trials Training Program (LuCTT) health disparities Lupus Education Advancement Project Source Type: research
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