Are you TORCing tau me? Amyloid-{beta} blocks the conversation between lysosomes and mitochondria

How amyloid-β (Aβ) and tau exacerbate Alzheimer's disease (AD) at a subcellular level is only incompletely understood. Norambuena et al (2018) report crosstalk between mitochondria and lysosomes and identify a role for lysosomal mTORC1 in the nutrient-induced activation of mitochondria. This lysosomal signalling pathway is strongly inhibited by oligomeric Aβ through the tau-dependent activation of plasma membrane-localized mTORC1. Together, these results identify a further role for tau in mediating Aβ toxicity.

http://emboj.embopress.org/cgi/content/short/37/22/e100839?rss=1

Source: EMBO Journal - November 15, 2018 Category: Molecular Biology Authors: Polanco, J. C., Götz, J. Tags: Autophagy & Cell Death, Metabolism, Neuroscience News [amp ] Views Source Type: research