Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Publication date: December 2018Source: The Lancet Neurology, Volume 17, Issue 12Author(s): Joseph Raymond Zunt, Nicholas J Kassebaum, Natacha Blake, Linda Glennie, Claire Wright, Emma Nichols, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Abdu A Adamu, Mina G. Adib, Alireza Ahmadi, Muktar Beshir Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Nadia Akseer, Rajaa M Al-Raddadi, Fares Alahdab, Kefyalew Addis AleneSummaryBackgroundAcute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes.MethodsThe Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2016 study estimated meningitis burden due to one of four types of cause: pneumococcal, meningococcal, Haemophilus influenzae type b, and a residual category of other causes. Cause-specific mortality estimates were generated via cause of death ensemble modelling of vital registration and verbal autopsy data that were subject to standardised data processing algorithms. Deaths were multiplied by the GBD standard life expectancy at age of death to estimate years of life lost, the mortality component of disability-adjusted life-years (DALYs). A systematic analysis of relevant publications and hospital and claims data was used to estimate meningitis incide...
Source: The Lancet Neurology - Category: Neurology Source Type: research