Pattern and prognostic value of FLT3 ‐ITD mutations in Chinese de novo adult acute myeloid leukemia

A total of 227 FLT3 ‐ITD sequences were analyzed from 227 Chinese adult de novo acute myeloid leukemia (AML) patients. ITD could be classified into 3 types based on molecular profiles. ITD integration sites in the hinge region or beta1‐sheet region are an unfavorable prognostic factor in adult AML patients with FLT 3‐ITD mutations. FMS ‐like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in hematological malignancies.FLT3 internal tandem duplication (FLT3‐ITD) mutations located in juxtamembrane domain (JMD) and tyrosine kinase domain 1 (TKD1) regions account for two‐thirds of allFLT3 mutations. The outcome of patients remains unsatisfactory, with low survival rates. It is not yet known whether the different mutations within theFLT3 gene are all associated with patient outcome. In addition, the cause ofFLT3‐ITD in‐frame duplication events remains unknown. Although there are some published studies investigating theFLT3‐ITD mutation and its clinical implications in Chinese acute myeloid leukemia (AML) patients, sample sizes tend to be small and detailed molecular profiles ofFLT3 mutations are lacking in these studies. In our study, 227FLT3‐ITD sequences were analyzed from 227 Chinese de novo AML patients. ITD were next classified into 3 types based on molecular profiles of insertion DNA sequences: DNA complete duplication (type I), DNA partial duplication (type II) and complete random sequence (type III). From the 154 patients, we confir...
Source: Cancer Science - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research