Expanded diagnostic approach to hepatitis E virus detection in patients with acute-on-chronic liver failure: A pilot study

Conclusion: This study shows that alcohol is a major contributing factor for both underlying CLD and ACLF while HEV is the most common infectious cause for ACLF, suggesting a need for a vaccination in such patients, whenever made available.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research

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Authors: Ayoola R, Larion S, Poppers DM, Williams R Abstract BACKGROUND: Hepatitis B virus is a viral infection that can lead to acute and/or chronic liver disease, and hepatocellular carcinoma (HCC). Hepatitis B vaccination is 95% effective in preventing infection and the development of chronic liver disease and HCC due to hepatitis B. In 2011, the Centers for Disease Control updated their guidelines recommending that adults at high-risk for hepatitis B infection be vaccinated against hepatitis B including those with diabetes mellitus (DM). We hypothesize that adults at high-risk for hepatitis B infection are not ...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Non-alcoholic fatty liver disease (NAFLD), a condition of extra fat buildup in the liver, is on the rise — it now affects roughly 20% to 40% of the US population. It usually doesn’t cause any symptoms, and is often first detected by accident when an imaging study (such as an abdominal ultrasound, CT scan, or MRI) is requested for another reason. A fatty liver may also be identified on an imaging test as a part of investigating abnormal liver blood tests. NAFLD is intimately related to conditions like diabetes and obesity. It’s also linked to an increased risk of cardiovascular disease. Understanding NAFLD...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Health Source Type: blogs
ConclusionsVersion 9.0 of the EACS Guidelines provides a holistic approach to HIV care and is translated into the six most commonly spoken languages.
Source: HIV Medicine - Category: Infectious Diseases Authors: Tags: European AIDS Clinical Society (EACS) Guideline Source Type: research
Discussion It is estimated that 180 million people worldwide are infected with Hepatitis C (HCV) which includes ~11 million children. In the United States it is estimated that there were 30,500 acute HCV cases in 2014, and 2.7-3.9 million people with chronic HCV. Many infections are not identified. It is estimated that “…only 5-15% of HCV-infected children in the United States are identified.” Problems associated with HCV include acute hepatitis (including fever, malaise, dark-urine, abdominal pain, jaundice, appetite loss, nausea, emesis, clay-colored stools), acute fulminant hepatitis (not common in c...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
There is much to report from the realm of liver tumors. The incidence of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma, is increasing worldwide. Although direct acting antivirals and vaccination protocols provide hope of decreasing the burden of chronic hepatitis C and B respectively as leading causes of HCC, the global epidemic of fatty liver disease and metabolic syndrome appears to provide a novel and rather fertile milieu for the development of HCC. Many HCCs arising in a background of non-alcoholic fatty liver disease occur in the absence of cirrhosis and these tumors may recapitulate the fea...
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research
Authors: Abstract All women are at risk of acute and chronic liver diseases. Of particular importance are those diseases that exclusively affect pregnant women and have adverse effects on maternal, fetal, or neonatal outcomes. Acute viral hepatitis is an important cause of liver disease in pregnant women, and hepatitis E infection is associated with substantial mortality. An increasing number of women have chronic liver diseases caused by viral hepatitis, alcoholic liver disease and nonalcoholic fatty liver disease, autoimmune liver diseases, and genetic liver diseases. The presence of chronic liver diseases or c...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
We read the article by Minesh Mehta et al. published in Digestive and Liver Disease with great interest [1]. The authors state that paediatric patients with non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH) are not sufficiently protected against hepatitis B virus (HBV), which is associated with impaired response to the hepatitis B vaccine. In cited study, 72% of patients were considered non-immune to HBV. Based on results of aforementioned study and other literature reports, the authors suggested that obesity is the primary predictor of diminished immunogenic response to HBV-vaccine and ...
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
The implementation of a hepatitis B vaccination program in China has led to a significant decline in the prevalence and incidence of liver diseases secondary to hepatitis B virus over the past two decades. With recent changes in the economy and increases in average incomes in China during the same period, there has been a rapid rise in per capita alcohol consumption and an epidemic of obesity. We hypothesized that the burden of liver diseases in China has shifted from infectious to non-infectious etiologies.
Source: Alcohol - Category: Addiction Authors: Source Type: research
We report a professional rugby player, incidentally found to have chronic HBV infection. Born before 1995, his HBV acquisition was likely in childhood before age 5, in keeping with HBV epidemiology in sub-Saharan Africa. He used no alcohol, illicit substances or performance enhancing drugs. Table 1 lists his workup identifying the immune clearance/active phase of chronic...
Source: British Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Editorial Source Type: research
This study assessed the programmatic implementation of a multi-disciplinary program to prevent hepatocellular carcinoma through hepatitis C (HCV) testing, secondary prevention among diagnosed individuals (defined as interventions that prevent further progression of liver disease), and treatment within a medically and minority underserved clinic.The Lewis Cancer &Research Pavilion (LCRP) at St. Joseph's/Candler Health System is a Community Cancer Center and regional destination for cancer care in coastal Georgia. LCRP disparities efforts focus on cancer prevention, screening, and facilitating access to cancer care at tw...
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Community-Based Interventions: Poster Presentations - Proffered Abstracts Source Type: research
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