Cell-free biomanufacturing

Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Bradley C Bundy, J Porter Hunt, Michael C Jewett, James R Swartz, David W Wood, Douglas D Frey, Govind RaoSince its early development and use to decipher the genetic code, in vitro or ‘cell-free’ systems have been used as an important research tool to understand biochemical mechanisms and metabolic pathways. More recently, due to important engineering advances the technology is rapidly becoming a biomanufacturing platform for protein therapeutics, vaccines, enzyme biocatalysts, fuels, and commodity chemicals. Here we report recent applications and advances in the cell-free biomanufacturing field and the potential of this emerging approach.

Source: Current Opinion in Chemical Engineering - November 14, 2018 Category: Chemistry Source Type: research