UV-light intervened synthesis of imidazo fused quinazoline and its solvatochromism, antioxidant, antifungal and luminescence properties

Publication date: Available online 13 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Duraipandi Devipriya, Selvaraj Mohana RoopanAbstractThe photochemical preparation of benzo[4,5]imidazo[2,1-b]quinazoline was assessed under the illumination of UV wavelength (>360 nm). The compound 3,4-dihydronaphthalen-1(2H)-one 1 with 1H-benzo[d]imidazol-2-amine 2 in the existence of KOH/DMF which lead to the aromatized compound 3. The notable remark of this reaction is that the UV irradiation (312 nm) plays a vital part in the formation of the compound, 3 in shorter duration (2 h) which resulted in the reaction gave was higher yield (96%). Compound 3 was analyzed by H1, C13 NMR, and HRMS. Solvatochromism impacts of the compound 3 was computed with deference (DCM < methanol< DMF < DMSO). The compound, 3 was presented to invitro free radical screening utilizing DPPH strategy and furthermore H2O2 technique. The standard ascorbic acid has less IC50 value esteem than compound 3. Further, it was subjected to in vitro fungicidal action against two Aspergillus species (A. flavus & niger). The anti-fungal activity of compound 3 additionally demonstrated great action, when compared antifungal specialist Fluconazole.Graphical Abstract
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research