Pfizer's Pristiq Phase IV trial shows low potential for sexual dysfunction in MDD patients

Pfizer has reported positive results from its Phase IV clinical trial of Pristiq (desvenlafaxine) in adult patients with major depressive disorder (MDD).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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Authors: Rothmore J Abstract Sexual dysfunction is a frequent, potentially distressing, adverse effect of antidepressants and a leading cause of medication non-adherence. Sexual function should be actively assessed at baseline, at regular intervals during treatment, and after treatment cessation. Trials comparing the risk of sexual dysfunction with individual antidepressants are inadequate, but it is reasonable to conclude that the risk is greatest with selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs), less with tricyclic antidepressants (except clomipramin...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Abstract Pregnant adolescents are at risk for micronutrient deficiency, psychological problems, and sexual dysfunction. We aimed to determine serum levels of vitamin D, calcium, magnesium, and copper, and also their relations with stress, anxiety, depression, and sexual function in pregnant adolescents. This cross-sectional study was conducted on two hundred 11-19-year-old healthy singleton pregnant women at gestational age of 26-32 weeks, who were covered by public health centers in Tabriz, Iran. Depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS), anxiety and stress using the Depre...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
CONCLUSIONS: Our study shows that vilazodone has similar efficacy but can be a better antidepressant due to lesser weight gain and sexual dysfunction compared to sertraline.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSIONS: None of the websites met our predefined criteria. The information was generally inaccurate and unhelpful and has potential to lead to inappropriate use and overuse of antidepressants and reduce the likelihood that people will seek better options for depression like psychotherapy. PMID: 32144998 [PubMed - as supplied by publisher]
Source: International Journal of Risk and Safety in Medicine - Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
 Did you know one in six males are sexually assaulted before their 18th birthday? Unfortunately, many victims are reluctant to come forward due to cultural conditioning. In today’s podcast, Gabe speaks with two psychologists about this very common but somewhat taboo issue. They tackle the prevalent myths surrounding male sexual assault and discuss why so many victims suffer in secrecy. What can be done? Where can survivors reach out for help? Join us for an in-depth talk on this very important and under-discussed topic. SUBSCRIBE &REVIEW Guest information for ‘Male Sexual Assault’ Podcast Episod...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Abuse Children and Teens General Interview Men's Issues Podcast The Psych Central Show Trauma Source Type: blogs
CONCLUSION: Sexual therapy, administration of OnabotulinumtoxinA, pelvic floor muscles exercises alone or combined with electrostimulation and the use of clitoral devices could be the most recommended interventions to improve the sexuality in women with multiple sclerosis. PMID: 32048535 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - Category: Rehabilitation Authors: Tags: Clin Rehabil Source Type: research
AbstractHereditary spastic paraplegias (HSP) share as cardinal feature progressive spastic gait disorder. SPG4 accounts for about 25% of cases and is caused by mutations in theSPAST gene. Although HSP is an upper motor neuron disease, the relevance of non-motor symptoms is increasingly recognized because of the potential response to treatment. Our study sets out to evaluate non-motor symptoms and their relevance with regard to health-related quality of life. In 118 genetically confirmed SPG4 cases and age- and gender-matched controls, validated questionnaires were used to evaluate fatigue, depression, pain, and restless le...
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractSexual dysfunction is one of the most common complaints of patients with multiple sclerosis (MS). The study aimed to determine the effect of counseling based on the extended PLISSIT model (Permission, Limited Information, Specific Suggestion, and Intensive Therapy) on sexual dysfunction and the quality of sexual life of married women with MS. This randomized clinical trial was performed on 70 married women with MS aged between 18 and 45  years referring to the MS Association of Tabriz, Iran. The data were collected using a demographic questionnaire, Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (M...
Source: Sexuality and Disability - Category: Disability Source Type: research
 In today’s digital culture, sex is easy to find. But most of our encounters with it are shallow and unrealistic. Sexual images and films easily capture the lust, or carnality, of sex, but there is very little conversation surrounding intimacy and how sex actually works in a real human relationship. In fact, many people believe there is something wrong with them because their sex life doesn’t look like it does in the media.  In this podcast, our guest Laurie Watson, sex therapist and licensed marriage and family counselor, discusses some of the most common sexual issues she encounters in her practice an...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Interview Marriage and Divorce Psychotherapy Relationships Sexuality The Psych Central Show Treatment Source Type: blogs
AbstractHidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severi...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
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