Dorsal root ganglion explants derived from chemotherapy-treated mice have reduced neurite outgrowth in culture

In conclusion, our results show that the effect of paclitaxel and oxaliplatin on the structural plasticity of DRG is retained ex vivo (for at least 30 days) and suggest the use of DRG explants derived from chemotherapy-treated mice as an efficient method to investigate the mechanisms underlying CIPN and test for possible therapeutic targets.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research