The inhibition of digitoxin on Store Operated Calcium Entry is dependent on the phosphorylation sites and pore region of Orai1.
CONCLUSIONS: Our study identified two sites critical for the inhibition on Orai1 channels, providing valuable targets for future design of SOCE inhibitors.
PMID: 30421677 [PubMed - as supplied by publisher]
Source: Epilepsy Curr - Category: Neurology Authors: Zhou L, Chi X, Zhu Y, Zhang T, Liu J, Ma G, He L, Zhang S, Gao P, Zhou Y, Liu J, Wang Y Tags: Curr Mol Med Source Type: research