The inhibition of digitoxin on Store Operated Calcium Entry is dependent on the phosphorylation sites and pore region of Orai1.

CONCLUSIONS: Our study identified two sites critical for the inhibition on Orai1 channels, providing valuable targets for future design of SOCE inhibitors. PMID: 30421677 [PubMed - as supplied by publisher]
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Mol Med Source Type: research