Real-life treatment of cholinergic urticaria with omalizumab

Cholinergic urticaria (CholU) is a frequent form of inducible urticaria, characterized by small itchy wheals induced by physical activity or passive warming. The underlying pathomechanisms of CholU are not completely understood. Several recent studies have provided evidence that IgE-mediated mast cell activation is of major importance in the pathogenesis of CholU.1-3 In line with this theory are observations, mostly from case reports, that patients with CholU can benefit from omalizumab (anti-IgE) treatment.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research