Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms*

Many commonly abused drugs paradoxically increase the incentive salience of contextual stimuli (Berridge and Robinson, 1998; Flagel et al., 2009; Robinson et al., 2015; Uslaner et al., 2006) while simultaneously conditioning avoidance responses to paired orosensory stimuli (Imperio and Grigson, 2015; Jenney et al., 2016; Liu et al., 2009; Parker, 1995, 2003). This is in contrast to the effects of primarily emetic stimuli, such as lithium chloride (LiCl), which result in both conditioned place and taste avoidance (CPA and CTA, respectively; Parker, 2003; Tenk et al., 2005, 2006).

Source: Drug and Alcohol Dependence - November 13, 2018 Category: Addiction Authors: G.C. Loney, P.J. Meyer Tags: Full length article Source Type: research