Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys

Drug addiction is a worldwide public health concern. Amphetamine-type stimulants are some of the most commonly used and abused drugs in the world (United Nations Office on Drugs and Crime, 2016). In particular, methamphetamine (METH) is a stimulant with a high potential for abuse, and its use has been increasing across the globe (United Nations Office on Drugs and Crime, 2016). METH blocks monoamine transporters and dopamine (DA) metabolism, also acting as a monoamine releaser, increasing DA concentration in the synapse of the nucleus accumbens (NAcc) (Ciccarone, 2011).
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Short communication Source Type: research