Cancers, Vol. 10, Pages 436: Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia

Cancers, Vol. 10, Pages 436: Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia Cancers doi: 10.3390/cancers10110436 Authors: Victor Pallarès Montserrat Hoyos M. Carmen Chillón Eva Barragán M. Isabel Prieto Conde Marta Llop Aïda Falgàs María Virtudes Céspedes Pau Montesinos Josep F. Nomdedeu Salut Brunet Miguel Ángel Sanz Marcos González-Díaz Jorge Sierra Ramon Mangues Isolda Casanova In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration and apoptosis. They associate with metastatic dissemination in solid tumors and poor prognosis. However, their role in haematological malignancies has been scarcely studied. We hypothesized that PTK2/FAK, PTK2B/PYK2, LYN or SRC could be new prognostic markers in IR-AML. We assessed PTK2, PTK2B, LYN and SRC gene expression in a cohort of 324 patients, adults up to the age of 70, classified in the IR-AML cytogenetic group. Univariate and multivariate analyses showed that PTK2B, LYN and PTK2 gene expression are independent prognostic factors in IR-AML patients. PTK2B and LYN identify a patient subgroup with good prognosis within the cohort with non-favorable FLT3/NPM1 combined mutations. In contrast, PTK2 id...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research