Cancers, Vol. 10, Pages 436: Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
Cancers, Vol. 10, Pages 436: Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
Cancers doi: 10.3390/cancers10110436
Authors:
Victor Pallarès
Montserrat Hoyos
M. Carmen Chillón
Eva Barragán
M. Isabel Prieto Conde
Marta Llop
Aïda Falgàs
María Virtudes Céspedes
Pau Montesinos
Josep F. Nomdedeu
Salut Brunet
Miguel Ángel Sanz
Marcos González-Díaz
Jorge Sierra
Ramon Mangues
Isolda Casanova
In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration and apoptosis. They associate with metastatic dissemination in solid tumors and poor prognosis. However, their role in haematological malignancies has been scarcely studied. We hypothesized that PTK2/FAK, PTK2B/PYK2, LYN or SRC could be new prognostic markers in IR-AML. We assessed PTK2, PTK2B, LYN and SRC gene expression in a cohort of 324 patients, adults up to the age of 70, classified in the IR-AML cytogenetic group. Univariate and multivariate analyses showed that PTK2B, LYN and PTK2 gene expression are independent prognostic factors in IR-AML patients. PTK2B and LYN identify a patient subgroup with good prognosis within the cohort with non-favorable FLT3/NPM1 combined mutations. In contrast, PTK2 id...
Source: Cancers - Category: Cancer & Oncology Authors: Victor Pallar ès Montserrat Hoyos M. Carmen Chill ón Eva Barrag án M. Isabel Prieto Conde Marta Llop A ïda Falgàs Mar ía Virtudes Céspedes Pau Montesinos Josep F. Nomdedeu Salut Brunet Miguel Ángel Sanz Marcos Gonz ález-Díaz Jorge Sierra Ramon M Tags: Article Source Type: research
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