Isocitrate dehydrogenase 1 and 2 mutations, 2 ‐hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia

ConclusionsAmong patients withIDH1/2‐mutated AML, 2HG levels are highly specific for the mutational status at diagnosis, and they have prognostic relevance in patients receiving standard chemotherapy.

Source: Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Andrew M. Brunner, Donna S. Neuberg, Seth A. Wander, Hossein Sadrzadeh, Karen K. Ballen, Philip C. Amrein, Eyal Attar, Gabriela S. Hobbs, Yi ‐Bin Chen, Ashley Perry, Christine Connolly, Christelle Joseph, Meghan Burke, Aura Ramos, Ilene Ga Tags: Original Article Source Type: research