Solving the mystery of NPM1 in acute myeloid leukemia

(Baylor College of Medicine) Acute myeloid leukemia (AML) cells expressing the NPM1 mutant gene are highly dependent on continued export of protein NPM1c to proliferate. This finding provides a rationale for testing nuclear export inhibitor therapeutics in NPM1-mutated AML.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news