The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

Tyagi et  al. show that oral supplementation with the widely used probiotic, Lactobacillus rhamnosus GG (LGG), increases bone mass in mice by increasing the serum levels of the short chain fatty acid butyrate. LGG or butyrate increase the frequency of regulatory T (Treg) cells in the intestine and in the bo ne marrow. Treg cells stimulate CD8+ T cells to secrete the Wnt ligand Wnt10b, which stimulates bone formation by activating Wnt signaling in osteoblasts. Therefore, LGG and butyrate may represent new interventions for the prevention and treatment of osteoporosis.

Source: Immunity - November 13, 2018 Category: Allergy & Immunology Authors: Abdul Malik Tyagi, Mingcan Yu, Trevor M. Darby, Chiara Vaccaro, Jau-Yi Li, Joshua A. Owens, Emory Hsu, Jonathan Adams, M. Neale Weitzmann, Rheinallt M. Jones, Roberto Pacifici Tags: Article Source Type: research