C5a receptor 1 −/− mice are protected from the development of IgE‐mediated experimental food allergy

ConclusionsOur findings identify C5aR1 activation as an important driver of IgE ‐mediated food allergy through regulation of allergen‐specific IgE production, FcεR1‐mediated MC degranulation, and histamine‐driven effector functions preferentially in male mice.

Source: Allergy - November 12, 2018 Category: Allergy & Immunology Authors: Anna Kordowski, Anna T. Reinicke, David Wu, Zane Orinska, Philipp Hagemann, Markus Huber ‐Lang, Jee‐Boong Lee, Yui‐Hsi Wang, Simon P. Hogan, Jörg Köhl Tags: Original Article Source Type: research