Nipah Virus Infection of Immature Dendritic Cells Increases Its Transendothelial Migration Across Human Brain Microvascular Endothelial Cells

Vunjia Tiong, Meng-Hooi Shu, Won Fen Wong, Sazaly AbuBakar, Li-Yen Chang
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Av R, Sadanandan S, Thulaseedharan NK, Kg SK, Pallivalappil B, As AK Abstract Nipah Virus Infection is an emerging zoonotic infection which presents with acute encephalitis and respiratory distress syndrome. It is associated with high mortality and classified as Biosafety level 4 organisms in view of its features which make it a potential agent for Bioterrorism. Experience with broad spectrum antiviral agent Ribavirin is promising in reducing the mortality and morbidity. PMID: 31313551 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Isolating adults with respiratory symptoms resulting from Nipah virus infection may help stem the spread of the virus, a New England Journal of Medicinestudy suggests.
Source: JAMA - Category: General Medicine Source Type: research
This article reviews what has been learned from biochemical and structural studies on the VSV RNA biosynthesis machinery, and then focuses on recent advances in our understanding of regulatory and catalytic roles of the PRNTase domain in RNA synthesis and capping.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Findings help guide surveillance to prevent disease outbreaks More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298814&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
(Cary Institute of Ecosystem Studies) Since its discovery in 1999, Nipah virus has been reported almost yearly in Southeast Asia, with Bangladesh and India being the hardest hit. In a new study, published today in PLoS Neglected Tropical Diseases, scientists used machine learning to identify bat species with the potential to host Nipah virus, with a focus on India -- the site of a 2018 outbreak. Four new bat species were flagged as surveillance priorities.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
by Raina K. Plowright, Daniel J. Becker, Daniel E. Crowley, Alex D. Washburne, Tao Huang, P. O. Nameer, Emily S. Gurley, Barbara A. Han The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genusHenipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala,> 1800 km from the sites of previous outbreaks in eastern India in 2001 an...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
by Neeltje van Doremalen, Teresa Lambe, Sarah Sebastian, Trenton Bushmaker, Robert Fischer, Friederike Feldmann, Elaine Haddock, Michael Letko, Victoria A. Avanzato, Ilona Rissanen, Rachel LaCasse, Dana Scott, Thomas A. Bowden, Sarah Gilbert, Vincent Munster Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted i...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
India has put more than 300 people under surveillance after a 23-year-old man was diagnosed with the Nipah virus, a rare and often deadly disease.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
In this study, intermediate-size aerosol particles (~7 μm) of NiV-Malaysia were used to mimic potential routes of exposure by focusing viral deposition in the upper respiratory tract. Our previous report showed this route of exposure extended the disease course and a single animal survived the infection. Here, analysis of the peripheral immune response found minimal evidence of systemic inflammation and depletion of B cells during acute disease. However, the animal that survived infection developed an ear ly IgM response with rapid development of neutralizing antibodies that likely afforded protection. The increase in N...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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