PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis

AbstractWe have previously identified thatPPPDE1 is a deubiquitinase (DUB) belonging to a cysteine isopeptidase family. Here we sought to explore the biological significance ofPPPDE1 in hepatocellular carcinoma and its underlying molecular mechanism. In the present study, we found that amplification and overexpression ofPPPDE1 were associated with poor prognosis in hepatocellular carcinoma (HCC). We also demonstrated that knocking down ofPPPDE1 could significantly block the clonal growth and tumorigenicity of human HCC cells, which revealed a critical role forPPPDE1 in HCC development. Furthermore, we proved thatPPPDE1 is a key modulator of p53 protein level and its down stream apoptosis pathway. Taken together, these results suggested thatPPPDE1 is a putative HCC driver gene and extensive studies should be conducted in the future to investigate the role ofPPPDE1 in HCC and other tumors.
Source: Apoptosis - Category: Molecular Biology Source Type: research