Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model.
DISCUSSION: Transfused platelets serve as an adjuvant in this T-dependent murine model of anti-KEL red blood cell alloimmunisation, with CD40/CD40L interactions being involved to some degree but with additional mechanisms also playing a role. These findings raise questions about the role that transfused or endogenous platelets may play in other innate/adaptive immune responses.
PMID: 30418129 [PubMed - as supplied by publisher]
Source: Blood Transfusion - Category: Hematology Authors: Madrid DJ, Santhanakrishnan M, Liu J, Gibb DR, Liu D, Natarajan P, Beitler D, Shi Z, Mo C, Tormey CA, Patel SR, Stowell SR, Hendrickson JE Tags: Blood Transfus Source Type: research
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