Microbes and their metabolites correlate with HSCT outcomes?

The process of allogeneic (allo) hematopoietic stem cell transplantation (HSCT) causes loss of diversity and alters the composition of the intestinal microbiota by antibiotic treatment and the development of acute graft versus host disease (aGVHD)[1]. Conversely, the intestinal microbiota has been shown to modulate post allo HSCT outcomes including severity and mortality from aGVHD, bloodstream infections, overall survival, and relapse [2-5]. The mechanisms underpinning these effects on allo HSCT clinical outcomes could involve alterations in the quality and quantity of microbial metabolites such as short chain fatty acids (SCFAs) that accompany changes in the bacterial composition [6].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research