Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder

Childhood critical periods of experience-dependent plasticity are essential for the development of environmentally appropriate behavior and cognition. Disruption of critical periods can alter development of normal function and confer risk for neurodevelopmental disorders. While genes and their expression relevant to neurodevelopment are associated with schizophrenia, the molecular relationship between schizophrenia and critical periods has not been assessed systematically. Here, we apply a transcriptome-based bioinformatics approach to assess whether genes associated with the human critical period for visual cortex plasticity, a well-studied model of cortical critical periods, are aberrantly expressed in schizophrenia and bipolar disorder.

Source: Schizophrenia Research - November 12, 2018 Category: Psychiatry Authors: Milo R. Smith, Ben Readhead, Joel T. Dudley, Hirofumi Morishita Source Type: research