Glad Your EF Is Better, But Stay on Your Meds Glad Your EF Is Better, But Stay on Your Meds

While the TRED-HF trial may not be great news for patients with dilated cardiomyopathy and recovered EF, at least it eases this physician's conscience about her reluctance to curtail pharmacotherapy.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Expert Column Source Type: news

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Conclusions: Remodeling was similar in ARC and in cardiomyocytes of DCM suggesting evolutionary conserved mechanisms of regeneration. Despite activation of fetal genes, the atrophy of ARC indicates differences in their regenerative capacity from NRC. Cardiac-derived factors induced NM-actinin expression and increased survival of ischemic ARC while circulating molecules were less effective. Identification of these cardiac-derived factors and determination of their individual capacity to heal or damage are of particular importance for a biomarker-guided therapy in adult patients. PMID: 32774516 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Heart failure (HF) with reduced contractile function is a common and lethal syndrome in which the heart cannot pump blood to adequately meet bodily demands, resulting in high mortality despite the current standard of care. In modern societies, the most common drivers of HF are ischemic heart disease and hypertension. However, in a substantial subset of cases, patients present with dilated and poorly contracting hearts without evidence of common inciting stressors, a syndrome called dilated cardiomyopathy (DCM). Genome sequencing has identified a host of deleterious germline variants in key cardiomyocyte genes as causes of ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We report that deletion of Lmna in cardiomyocytes in mice leads to severe cardiac dysfunction, conduction defect, ventricular arrhythmias, fibrosis, apoptosis, and premature death within 4 weeks. The phenotype is similar to LMNA-associated cardiomyopathy in humans. RNA sequencing, performed before the onset of cardiac dysfunction, led to identification of 2338 differentially expressed genes (DEGs) in Lmna-deleted cardiomyocytes. DEGs predicted activation of bromodomain-containing protein 4 (BRD4), a regulator of chromatin-associated proteins and transcription factors, which was confirmed by complementary approaches, includ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractPurpose of ReviewThis review aims to give an update on recent findings related to the cardiac splicing factor RNA-binding motif protein 20 (RBM20) and RBM20 cardiomyopathy, a form of dilated cardiomyopathy caused by mutations inRBM20.Recent FindingsWhile most research on RBM20 splicing targets has focused on titin (TTN), multiple studies over the last years have shown that other splicing targets of RBM20 including Ca2+/calmodulin-dependent kinase II δ (CAMK2D) might be critically involved in the development of RBM20 cardiomyopathy. In this regard, loss of RBM20 causes an abnormal intracellular calcium handlin...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
ConclusionNuclear localization of OPN in cardiomyocytes of patients with CAV was evident at the time of cardiac retransplant as well as in patients with DCM at the time of the 1st transplant. The results implicate nuclear OPN as a novel biomarker for severe CAV and DCM.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study aimed to determine the relationship between RR‐NSVT and the occurrence of ventricular tachyarrhythmias (VTAs) in DCM p atients with ICD.MethodsFrom December 2000 to December 2017, 136 DCM patients received ICD or cardiac resynchronization therapy defibrillator (CRT ‐D) implantation for primary or secondary prevention of VTAs. Based on the occurrence of documented RR‐NSVT, patients were classified into RR‐NSVT (−) or RR‐NSVT (+) groups.ResultDuring the median follow ‐up of 4.5 years, 50.0% (68/136) patients experienced ≥1 episode, and 25.0% (34/136) patients experienced ≥3 episodes of RR...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: DEVICE Source Type: research
Nature Reviews Cardiology, Published online: 11 August 2020; doi:10.1038/s41569-020-0432-6A new clinical trial in a dish study sheds light on a new mechanism that restores endothelial dysfunction with lovastatin in induced pluripotent stem cells that are derived from patients with dilated cardiomyopathy.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
Previous experimental studies have provided evidence of notable changes in thyroid hormone signaling that corresponds to alterations in myocardial function in animal models of heart failure (HF). The present study further explores whether oral thyroid hormone treatment can change left ventricular (LV) mechanics and functional status in patients with idiopathic dilated cardiomyopathy (IDCM) or not.
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Source Type: research
Abstract Organ transplant from donors with ventricular assist devices is not common. Here, we report organ retrieval from a donor with a left ventricular assist device who had been on the heart transplant wait list before a brain death diagnosis. The organ donor was diagnosed with dilated cardiomyopathy and underwent left ventricular assist device surgery for bridging to heart transplant in 2016. Brain death occurred 22 months after implantation of the device at the age of 39 years due to widespread intraparenchymal and subarachnoid hemorrhage. Brain death diagnosis was confirmed with brain perfusion single-photon...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
AbstractAimsCardiomyopathies comprise a heterogeneous group of diseases, often of genetic origin. We assessed the current practice of genetic counselling and testing in the prospective European Society of Cardiology EURObservational Research Programme Cardiomyopathy Registry.Methods and resultsA total of 3208 adult patients from 69 centres in 18 countries were enrolled. Genetic counselling was performed in 60.8% of all patients [75.4% in hypertrophic cardiomyopathy (HCM), 39.2% in dilated cardiomyopathy (DCM), 70.8% in arrhythmogenic right ventricular cardiomyopathy (ARVC), and 49.2% in restrictive cardiomyopathy (RCM),P 
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
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