Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study

Conclusion: Based on our study, decreased C3 concentrations can be used as one of the risk factors that can help predict the need for acute dialysis and a more severe course of disease in children with diarrhea-associated hemolytic uremic syndrome.What is Known:•Shiga toxin modulates the function of complement regulatory proteins and thus contributes to complement activation in patients with diarrhea-associated hemolytic uremic syndrome.•Risk factors that can predict the need for acute renal replacement therapy and poor outcome in patients with diarrhea-associated hemolytic uremic syndrome are mainly the combination of oligoanuria, dehydration, leukocytosis, high hematocrit>  23%, and neurological involvement.What is New:•A lowered concentration of C3 at the time of initial presentation of diarrhea-associated hemolytic uremic syndrome was associated with more severe renal failure and the need for renal replacement therapy along with the development of more extra renal complications.•Decreased C3 at admission can predict complicated course of diarrhea-associated hemolytic uremic syndrome.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research