Erythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPKs activation through erythropoietin receptors on Schwann cells in a rat model of peripheral neuropathy

In conclusion, binding of EPO to its receptors on Schwann cells maintains myelin integrity and blocks ectop ic discharges in the injured median nerve, that in the end contribute to attenuation of neuropathic pain via reducing glutamate release from primary afferents and inhibiting activation of microglial MAPKs and production of pro‐inflammatory cytokines.

Source: Glia - November 11, 2018 Category: Neurology Authors: Chun ‐Ta Huang, Seu‐Hwa Chen, Shih‐Chang Lin, Wei‐Ting Chen, June‐Horng Lue, Yi‐Ju Tsai Tags: Research Article Source Type: research