Cancers, Vol. 10, Pages 433: Cell Origins of High-Grade Serous Ovarian Cancer
Cancers, Vol. 10, Pages 433: Cell Origins of High-Grade Serous Ovarian Cancer
Cancers doi: 10.3390/cancers10110433
Authors:
Jaeyeon Kim
Eun Young Park
Olga Kim
Jeanne M. Schilder
Donna M. Coffey
Chi-Heum Cho
Robert C. Bast
High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is the most common and deadliest type of ovarian cancer. HGSC appears to arise from the ovary, fallopian tube, or peritoneum. As most HGSC cases present with widespread peritoneal metastases, it is often not clear where HGSC truly originates. Traditionally, the ovarian surface epithelium (OSE) was long believed to be the origin of HGSC. Since the late 1990s, the fallopian tube epithelium has emerged as a potential primary origin of HGSC. Particularly, serous tubal intraepithelial carcinoma (STIC), a noninvasive tumor lesion formed preferentially in the distal fallopian tube epithelium, was proposed as a precursor for HGSC. It was hypothesized that STIC lesions would progress, over time, to malignant and metastatic HGSC, arising from the fallopian tube or after implanting on the ovary or peritoneum. Many clinical studies and several mouse models support the fallopian tube STIC origin of HGSC. Current evidence indicates that STIC may serve as a precursor for HGSC in high-risk women carrying germline BRCA1 or 2 mutations. Yet not all STIC lesions appear to progress to clinical HGSCs, nor would all HGSCs arise from STIC lesions, even in high-risk women. Moreo...
Source: Cancers - Category: Cancer & Oncology Authors: Jaeyeon Kim Eun Young Park Olga Kim Jeanne M. Schilder Donna M. Coffey Chi-Heum Cho Robert C. Bast Tags: Review Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Fallopian Tube Cancer | Genetics | Ovarian Cancer | Ovaries | Peritoneal Cancer | Serous Carcinoma | Study | Women