Overexpression of novel lncRNA NLIPMT inhibits metastasis by reducing phosphorylated glycogen synthase kinase 3 β in breast cancer

A novel long noncoding RNA was found to inhibit mammary cell proliferation and motility. Inhibition of glycogen synthase kinase 3 β (GSK3β) activity restored novel lncRNA inhibiting proliferation and metastasis‐induced repression. AbstractLong noncoding RNAs (lncRNAs) are considered as regulators of gene expression in cancers. However, cancer profiling has little focused on noncoding genes. Here, we reported that RP11 –115N4.1 (here renamed novel lncRNA inhibiting proliferation and metastasis [NLIPMT]) was downregulated in breast cancer tissues. Ectopic expression of NLIPMT inhibited mammary cell proliferation, motility in vitro. Moreover, lnc‐NLIPMT reduced the growth of implanted MDA‐MB‐231 cells in viv o. Mechanistically, glycogen synthase kinase 3β (GSK3β) was identified as an effector protein regulated by lnc‐NLIPMT. Inhibition of GSK3β activity restored NLIPMT‐induced inhibition of proliferation and motility in breast cancer cells. These data reveal that lnc‐NLIPMT functions as a drive r of breast cancer progression and might serve as a potential target for antimetastatic therapies.

Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Yang Jiang, Lili Lin, Shen Zhong, Yangjun Cai, Fen Zhang, Xiaobo Wang, Rongrong Miao, Baodan Zhang, Shenmeng Gao, Xiaoqu Hu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research