Non-B DNA Structures as Candidate Drug Targets Against Structural Chromosomal Instability

Conclusion: Hairpin/cruciform or slipped-strand DNA structures extruded by inverted and direct repeats, respectively, could be involved in the induction of translocations, deletions, isochromosomes, duplications and inversions in human cancers and genetic diseases as well as the expansion of short nucleotide repeats in hereditary neurological diseases. In addition, there is a significant association between long inverted repeats (LIRs) and the breakpoint regions of gross gene deletions in human cancers and inherited diseases. Thus, this review will focus on non-B DNA structures as candidate drug targets against structural chromosomal instability in various diseases.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research