Chronic Histamine 3 Receptor Antagonism Alleviates Depression like Conditions in mice via Modulation of Brain-Derived Neurotrophic Factor and Hypothalamus-Pituitary Adrenal Axis

Modulation of histaminergic activity has been shown to be involved in several physiological functions, such as circadian rhythm, energy homeostasis, sensory and motor functions, cognition, and attention, which are affected in several central nervous system(CNS) disorders (Haas and Panula, 2003; Leurs et al., 2005). All actions of histamine (HA) are orchestrated by four HA receptors, H1-H4R, which are members of the G-protein-coupled receptor (GPCR) family (Haas and Panula, 2003). Out of four HA receptors, H3R is of particular interest concerning CNS functions.

Source: Psychoneuroendocrinology - November 11, 2018 Category: Psychiatry Authors: Ajeet Kumar, Shalini Dogra, Chandan Sona, Deepmala Umrao, Mamunur Rashid, Sandeep K Singh, Muhammad Wahajuddin, Prem N Yadav Source Type: research