The Impact of Tacrolimus Exposure on Extrarenal Adverse Effects in Adult Renal Transplant Recipients

ConclusionsSeveral AEs (i.e., diarrhea, dyspepsia, insomnia, and neurologic AE ratio) were associated with tacrolimus dose normalized AUCss,0 ‐12hr, and clearance. Skin changes and acne were associated with dose ‐normalized CMAX concentrations. To facilitate clinical implementation, a LSS was developed to predict AUCss,0 ‐12hr values using sparse patient data to efficiently assess projected immunosuppressive exposure and potentially minimize AE manifestations.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research