Neural regulation of drug resistance in cancer treatment

Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Dan Liu, Xiaoxi Li, Xintian Chen, Yu Sun, Anqun Tang, Zhongwei Li, Junnian Zheng, Ming ShiAbstractThe treatment of cancer has made great progress. However, drug resistance remains problematic. Multiple physiologic processes of tumor development can be dominated by central and sympathetic nervous systems. The interactions between the nervous system, immune system, and tumor occur consistently and dynamically. Recent evidence suggests that nerves and neural signals are intimately involved in the development of resistance to cancer therapies. In this review, we will provide an overview of the recent progress in this rapidly growing area and discuss the potential new strategies for targeting the neural signaling pathway to improve the effectiveness of chemotherapies, targeted therapies, and immunotherapies.
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research

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