Functionalized MoS2 Nanovehicle with Near ‐Infrared Laser‐Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria‐Infected Wound Therapy

A novel 808 nm laser ‐mediated nitric oxide (NO)‐releasing nanovehicle (MoS2‐BNN6) based on simple assembly of α‐ cyclodextrin‐modified MoS2 nanosheets with a heat ‐sensitive NO donor (BNN6) is developed. The nanovehicle possesses a synergetic photothermal therapy/NO antibacterial function for low‐cost, rapid, and effective action against typical Gram's bacteria as well as promotion of wound healing. AbstractThe rising dangers of bacterial infections have created an urgent need for the development of a new generation of antibacterial nanoagents and therapeutics. A new near ‐infrared 808 nm laser‐mediated nitric oxide (NO)‐releasing nanovehicle (MoS2‐BNN6) is reported through the simple assembly of α‐cyclodextrin‐modified MoS2 nanosheets with a heat ‐sensitive NO donorN,N′‐di‐sec‐butyl‐N,N′‐dinitroso‐1,4‐phenylenediamine (BNN6) for the rapid and effective treatment of three typical Gram‐negative and Gram‐positive bacteria (ampicillin‐resistantEscherichia coli, heat ‐resistantEscherichia faecalis, and pathogenStaphylococcus aureus). This MoS2‐BNN6 nanovehicle has good biocompatibility and can be captured by bacteria to increase opportunities of NO diffusion to the bacterial surface. Once stimulated by 808 nm laser irradiation, the MoS2‐BNN6 nanovehicle not only exhibits photothermal therapy (PTT) efficacy but also can precisely control NO release, generating oxidative/nitrosative stress. The temperature‐enhanced cata...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research