Polydopamine doped reduced graphene oxide/mesoporous silica nanosheets for chemo-photothermal and enhanced photothermal therapy

Publication date: Available online 1 November 2018Source: Materials Science and Engineering: CAuthor(s): Rong Liu, Huicong Zhang, Fangrong Zhang, Xuandong Wang, Xiaolong Liu, Yun ZhangAbstractThe nanoplatform of synergistic chemo-photothermal therapy has superior advantages on antitumor. It is urgently needed to explore novel nanocarrier for improving photothermal performance in drug delivery process. Herein, we synthesized polydopamine doped mesoporous silica-coated reduced graphene oxide (rGO/MSN/PDA) by simply adding dopamine hydrochloride into the oil-water biphasic reaction system as a multifunctional drug carrier for anticancer treatment, which combines chemotherapy and photothermal therapy. rGO/MSN/PDA showed nearly twice the photothermal conversion efficiency of mesoporous silica-coated graphene oxide (GO/MSN) due to the reduction of GO and doping with PDA. In addition, rGO/MSN/PDA showed a pH-response DOX release profiles, which means higher release of DOX in tumor cells. The cell experiments in vitro proved that rGO/MSN/PDA with a better biocompatibility compare to GO/MSN might offer a promising tool for improving the therapeutic effects of hepatocellular carcinoma cells through synergistic chemo-photothermal therapy.
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research