Immunohistochemical analysis of vocal cord polyps applying markers of squamous cell carcinogenesis

CONCLUSION: Only polyps that present with simple hyperplasia as the greatest mucosal change can be considered as benign formations.Pathohistologically detected atypia in polypoid changes of vocal cords, confirmed by molecular atypia with an increase of SC carcinogenesis markers, suggest their inclusion in studies of laryngeal carcinogenesis.Our results suggest that in problematic cases IHC analysis could be of interest in detection of biological aggressiveness in polypoid laryngeal tissue and beneficiary for polyp patients’ follow-up.Further research of laryngeal carcinogenesis markers and their meaning in fibrovascular polyps is of interest.
Source: Pathology Research and Practice - Category: Pathology Source Type: research