Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide

Zonisamide (ZNS) was originally developed as an antiepileptic drug and is a T-type calcium (Ca) channel inhibitor. A previous clinical trial found that ZNS shortened the duration of “off” time in patients with Parkinson's disease [1]. ZNS is also effective in resting tremor in patients with Parkinson's disease in which dopamine is not effective [2]. Moreover, ZNS was useful for the treatment of essential tremor. Several basic research studies have reported that other T-type Ca channel blockers were effective in treating experimental tremors [3].

Source: Journal of the Neurological Sciences - November 10, 2018 Category: Neurology Authors: Naoyuki Hara, Tomohisa Nezu, Keitaro Kobatake, Hiroyuki Morino, Hideshi Kawakami, Hirofumi Maruyama Tags: Letter to the Editor Source Type: research