The Effect of Aging and Pre-Donation Comorbidities on the Related PBSC Donor Experience: A Report from the Related Donor Safety Study (RDSafe)

Over the past decade, registries such as the National Marrow Donor Program (NMDP) have published detailed data describing the unrelated donor (URD) experience, identifying individuals at increased risk for pain and collection related symptoms, slower recovery, need for placement of a central venous line (CVL), and severe adverse events.1-6 In spite of the fact that roughly half of allogeneic hematopoietic cell (HSC) donations come from related donors (RD), data describing details of early toxicities and longer-term outcomes in these individuals are scarce, with only one large recent study that focused mainly on severe adverse events.

Source: Biology of Blood and Marrow Transplantation - November 10, 2018 Category: Hematology Authors: Michael A. Pulsipher, Brent R. Logan, Pintip Chitphakdithai, Deidre M. Kiefer, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, Susan F. Leitman, James W. Varni, Hati Kobusingye, RaeAnne M. Besser, John P. Miller, Rebecca J. Drexler, Aly Abdel-Mageed, Source Type: research