Age-dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross-sectional study.

CONCLUSION: Our data demonstrate an age dependency of female preponderance in MS except for PPMS. This could be influenced by the lifecycle of sex hormone secretion in women. In PPMS, a male preponderance was observed in all age-groups, which might point to pathophysiological mechanisms being less influenced by sex hormones.
PMID: 30411534 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - November 8, 2018 Category: Neuroscience Authors: Miclea A, Salmen A, Zoehner G, Diem L, Kamm CP, Chaloulos-Iakovidis P, Miclea M, Briner M, Kilidireas K, Stefanis L, Chan A, Evangelopoulos ME, Hoepner R Tags: CNS Neurosci Ther Source Type: research