Epigenetics of the Molecular Clock and Bacterial Diversity in Bipolar Disorder

Bipolar Disorder (BD) is a mood disorder, which is characterized by recurrent manic, depressive or mixed episodes. Even though many potential pathomechanisms of BD have been identified over the last decades, it is still largely unknown how these disease mechanisms interact with each other. Neurotransmitter dysbalances, neurotrophic factor imbalances, chronic inflammation, oxidative stress and disturbed circadian rhythms have been put forward as putative underlying mechanisms (Boland et al., 2012; Andreazza et al., 2008; Berk et al., 2011; Bengesser and Reininghaus, 2013; Tsai et al., 2012; Soczynska et al., 2011; Kapczinski 2011; Bengesser et al., 2016).

Source: Psychoneuroendocrinology - November 10, 2018 Category: Psychiatry Authors: S.A. Bengesser, S. M örkl, A. Painold, N. Dalkner, A. Birner, F.T. Fellendorf, M. Platzer, R. Queissner, C. Hamm, A. Maget, R. Pilz, A. Rieger, J. Wagner-Skacel, B. Reininghaus, H.P. Kapfhammer, E. Petek, K. Kashofer, B. Halwachs, P. Holzer, A. Waha, E.Z Source Type: research